ABSTRACT
Objective To study the effect of GTA/AVC dual inhibitors on C6 brain nerve glima cells.Methods MTT method was used to test the brain glioma cells activity of proliferation at different times(12 h,48 h,72 h), and using the flow cytometry to detect the change of cells cycle.Results It has obvious inhibitory effcets on C6 brain nerve glima cells, and it was the most obvious at 48 h.GTA/AVC dual inhibitor(2000 μg/mL) treatment group remarkbly rise the G0/G1 rate of celluar, S-phase cell ratio descend, and the cells apoptosis rate was markedly increased.Compared with the control group and the GTA/AVC dual inhibition (1000 μL/mL)treatment group , were significant difference(P<0.05).Conclusion regulating cells cycle progression.
ABSTRACT
Objective:To evaluate the soft and hard tissue changes of class II division 1 patients treated by Dynamax appliance. Methods:15 class II division 1 cases, whose hand-wrist radiographs were in FG-G stage, were treated by Dynamax appliance. After scanning the cephalometric tracing and transcripting into the special software of Winceph 7.0, the Cephalometrics analysis was preformed on pre-treatment and post-treatment. Results:After being treated by Dynamax appliance, the SNB, Co-GN,L1-NB,Cm-Sn-Ls was increased significantly,the ANB,Wits,U1-NA,overjet,overbite,Ns-Sn-Pos decreased significantly. Conclusion:Dynamax can effectively induce forward movement of mandible, improved esthetics on soft tissue profile and make face become normal.